Charles Darwin's Theory of Pangenesis

In 1868 in England, Charles Darwin [5] proposed his pangenesis [6] theory to describe the units of inheritance between parents and offspring and the processes by which those units control development in offspring. Darwin coined the concept of gemmules, which he said referred to hypothesized minute particles of inheritance thrown off by all cells of the body. The theory suggested that an organism's environment could modify the gemmules in any parts of the body, and that these modified gemmules would congregate in the reproductive organs of parents to be passed on to their offspring. Darwin's theory of pangenesis [6] gradually lost popularity in the 1890s when biologists increasingly abandoned the theory of inheritance of acquired characteristics (IAC), on which the pangenesis [6] theory partially relied. Around the turn of the twentieth century, biologists replaced the theory of pangenesis [6] with germ plasm theory and then with chromosomal theories of inheritance, and they replaced the concept of gemmules with that of genes [7].